Archive for October 2009
Metabolism Mnemonics
Currently, I am studying for two midterms, one of which is concerned with cellular metabolic pathways and their mechanisms. Glycolysis and the citric acid cycle (known also as the Kreb's cycle, the TCA cycle or the Szent-Györgyi-Krebs cycle) are of main concern at the moment. I thought I would publish the mnemonic devices I use to memorize these pathways and their associated enzymes here, both for my own future reference and the use of anyone who needs them:
Glycolysis —
Steps of glycolysis:
Cofactors most important to the pyruvate dehydrogenation complex:
Compounds involved in cycle:
Compounds involved in cycle:
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This corresponds to (indented steps are either requirements or products of that step):
C—OAAA
Glycolysis —
Steps of glycolysis:
Goodness Gracious Father Franklin Did Go By Picking Pumpkins to Prepare PieThus, the first emphasized letter of each of the above emphasized words relates to the following steps in glycolysis:
GlucoseThe enzymes involved in the above steps can be remembered with the following memory aid:
Glucose-6-Phosphate
Fructose-6-phosphate
Fructose-1,6-biphosphate
Dihydroxyacetone phosphate (DHAP)
Glyceraldehyde-3-phosphate
1,3-Biphosphoglycerate
3-Phosphoglycerate
2-Phosphoglycerate
Phosphoenolpyruvate
Pyruvate
High Profile People Act Too Glamorous, Picture Posing Every PlaceAgain, the first emphasized letter of each of the above emphasized words relates to the following enzymes involved in the above steps in glycolysis:
HexokinasePyruvate Dehydrogenation Complex (PDC) —
Phosphofructo isomerase
Phoshofructokinase
Aldolase
Triose phosphate isomerase
Glyceraldehyde-3-phosphate dehydrogenase
Phosphoglycerokinase
Phosphoglyceromutase
Enolase
Pyruvate kinase
Cofactors most important to the pyruvate dehydrogenation complex:
TLC? Fuck No.This corresponds to:
E1:Citric Acid Cycle —
TPP
E2:
Lipoic Acid
Coenzyme A
E3:
FAD
NAD+
Compounds involved in cycle:
Our City Is Kept Safe and Sound From MalaceThis corresponds to:
OxalacetateEnzymes involved in cycle:
Citrate
Isocitrate
Alpha-ketoglutamate
Succinyl-coA
Succinate
Fumarate
Malate
CAIK Sounds So Fucking Mint.This corresponds to:
Citrate synthaseUrea Cycle —
Aconitase
Iso-citrate dehydrogenase
Alpha-Ketoglutarate dehydrogenase
Succinyl-coA synthetase
Succinate dehydrogenase
Fumerase
Malate dehydrogenase
Compounds involved in cycle:
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This corresponds to (indented steps are either requirements or products of that step):
OrnithineEnzymes involved in cycle (OAAA are the enzymes responsible for the indented steps above):
Carboamyl Phosphate
Citruline
Aspartate
Argininosuccinate
Fumarate
Arginine
Urea
C—OAAA
Carboamyl phosphate synthaseHope these come to good use.
Ornithine transcarbamoxylase
Argininosuccinate synthase
Arginininosuccinase
Arginase
Tag :
Science,
University Life
